ABSTRACT
Meropenem es un compuesto del grupo carbapenem, con un amplio espectro antibacteriano y rápida actividad bactericida. Esta actividad es superior sobre bacilos gram negativos fermentadores como klebsiella sp y E. coli, e inferior sobre pseudomonas sp. Y A. baumannii. En cuanto a estas dos últimas bacterias, hay que hacer notar que la actividad de meropenem sobre pseudomonas sp pareciera ser bastante más rápida que la que ocurre sobre acinetobacter sp, aún cuando las CIM aparecen similares. La muerte bacteriana es más rápida sobre P. aeruginosa
Subject(s)
Humans , Bacterial Infections/drug therapy , Carbapenems/chemistry , beta-Lactam Resistance , Carbapenems/pharmacology , Gram-Negative Bacteria/drug effects , Imipenem/chemistry , Porins/drug effects , Drug Resistance, Multiple , Thienamycins/chemistryABSTRACT
Meropenem is more stable than imipenem to renal dehydropeptidase I and can be used as a monodrug. It is bactericidal against most grampositive and gramnegative, aerobic and anaerobic species. Compared to imipenem, meropenem is more active against pseudomonas aeuginosa, burkholderia cepacia and some multiresistant nosocomial gramnegative strains because it is less inductor of extended spectrum B lactamases but may favor resistance against other antibiotic groups by an efflux pump induction. Its systemicdistribution in the extracellular space includes the central nervous system and is most excreted by glomerular filtration. As meropenem is more soluble than imipenem, it can be administered in bolus. Security profile: it rarely causes seizures, a frecuent effect observed with imipenem during tratment of bacterial meningitis in children. Other adverse reactions (local pain, pruritus and diarrhea) are as frecuent as described with imipenem